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Article

NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.

Proceedings of the National Academy of Sciences of the United States of America - 26 Feb 2008

Wu Chuan-Jin, Ashwell Jonathan D

Abstract excerpt

The mechanism by which the Carma1-Bcl10-MALT1 (CBM) complex couples T cell antigen receptor (TCR) signaling to IkappaB kinase (IKK) and NF-kappaB activation is not known. Here, we show that Bcl10 undergoes K63-linked polyubiquitination in response to T cell activation and subsequently binds NEMO, the regulatory subunit of IKK. This interaction requires the ubiquitin-binding activity of NEMO. The sites of Bcl10...

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Source

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Identifiers

PMID: 18287044
DOI: 10.1073/pnas.0712313105
PMCID: PMC2268578

Genes

MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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NEMO recognition of ubiquitinated Bcl10 is required for T cell receptor-mediated NF-kappaB activation.PMID 18287044Read ↗

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