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Article

MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.

Molecular and cellular biology - 1 Feb 2010

Moreno-García Miguel E, Sommer Karen, Shinohara Hisaaki, Bandaranayake Ashok D, Kurosaki Tomohiro, Rawlings David J

Abstract excerpt

The adaptor protein CARMA1 is required for antigen receptor-triggered activation of IKK and JNK in lymphocytes. Once activated, the events that subsequently turn off the CARMA1 signalosome are unknown. In this study, we found that antigen receptor-activated CARMA1 underwent lysine 48 (K48) polyubiquitination and proteasome-dependent degradation. The MAGUK region of CARMA1 was an essential player in this event;...

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Identifiers

PMID: 20008554
DOI: 10.1128/MCB.01129-09
PMCID: PMC2815576

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MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-kappaB activity.PMID 20008554Read ↗

The activation of lymphocytes is in their CARMA.Semantic proximity Read ↗

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