Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

doi:10.1038/nature08638

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Article

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma.

Nature - 7 Jan 2010

Davis R Eric, Ngo Vu N, Lenz Georg, Tolar Pavel, Young Ryan M, Romesser Paul B, Kohlhammer Holger, Lamy Laurence, Zhao Hong, Yang Yandan, Xu Weihong, Shaffer Arthur L, Wright George, Xiao Wenming, Powell John, Jiang Jian-Kang, Thomas Craig J, Rosenwald Andreas, Ott German, Muller-Hermelink Hans Konrad, Gascoyne Randy D, Connors Joseph M, Johnson Nathalie A, Rimsza Lisa M, Campo Elias, Jaffe Elaine S, Wilson Wyndham H, Delabie Jan, Smeland Erlend B, Fisher Richard I, Braziel Rita M, Tubbs Raymond R, Cook J R, Weisenburger Dennis D, Chan Wing C, Pierce Susan K, Staudt Louis M

Abstract excerpt

A role for B-cell-receptor (BCR) signalling in lymphomagenesis has been inferred by studying immunoglobulin genes in human lymphomas and by engineering mouse models, but genetic and functional evidence for its oncogenic role in human lymphomas is needed. Here we describe a form of 'chronic active...

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Identifiers

PMID: 20054396
DOI: 10.1038/nature08638
PMCID: PMC2845535

Genes

BCR
CARD11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20054396-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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