Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignancies

29 Apr 2016

Abstract excerpt

PURPOSE OF REVIEW: The CARMA1/BCL10/MALT1 (CBM) complex is a multimeric signaling complex controlling several important aspects of lymphocyte activation. Gain-of-function mutations in the genes encoding CBM proteins or their upstream regulators are associated with lymphoid malignancies, whereas loss-of-function mutations lead to immunodeficiency. This review reports on recent findings advancing our understanding...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Lymphoblastic Leukemia research
Share to NF-κB Signaling Pathways
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27135977
DOI: 10.1097/moh.0000000000000257

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the CARMA1/BCL10/MALT1 complex in lymphoid malignanciesPMID 27135977Read ↗

The CBM-opathies—A Rapidly Expanding Spectrum of Human Inborn Errors of Immunity Caused by Mutations in the CARD11-BCL10-MALT1 ComplexSemantic proximity Read ↗

Oncogenic CARMA1 couples NF-κB and β-catenin signaling in diffuse large B-cell lymphomas.Semantic proximity Read ↗

Structural determinants of MALT1 protease activity.Semantic proximity Read ↗

Genetic errors of the human caspase recruitment domain-B-cell lymphoma 10-mucosa-associated lymphoid tissue lymphoma-translocation gene 1 (CBM) complex: Molecular, immunologic, and clinical heterogeneity.Semantic proximity Read ↗

Mechanistic Insights Into Immune Cell Dysregulation Mediated by Novel Heterozygous Variants in CARD11 and MALT1.Semantic proximity Read ↗

Lymphomagenic CARD11/BCL10/MALT1 signaling drives malignant B-cell proliferation via cooperative NF-κB and JNK activation.Semantic proximity Read ↗

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses.Semantic proximity Read ↗

Mechanistic understanding of the combined immunodeficiency in complete human CARD11 deficiency.Semantic proximity Read ↗

Clinical and Immunological Features of Human BCL10 DeficiencySemantic proximity Read ↗

A novel linker region truncating variant in BCL10 underlies a leaky immunodeficiency phenotype.Semantic proximity Read ↗

Inactivating mutations and overexpression of BCL10, a caspase recruitment domain-containing gene, in MALT lymphoma with t(1;14)(p22;q32).Semantic proximity Read ↗

Oncogene-induced MALT1 protease activity drives posttranscriptional gene expression in malignant lymphomasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.