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Article

Phosphorylation of the CARMA1 linker controls NF-kappaB activation.

Immunity - 1 Dec 2005

Sommer Karen, Guo Beichu, Pomerantz Joel L, Bandaranayake Ashok D, Moreno-García Miguel E, Ovechkina Yulia L, Rawlings David J

Abstract excerpt

PKC isoforms and CARMA1 play crucial roles in immunoreceptor-dependent NF-kappaB activation. We tested whether PKC-dependent phosphorylation of CARMA1 directly regulates this signaling cascade. B cell antigen receptor (BCR) engagement led to the progressive recruitment of CARMA1 into lipid rafts and to the association of CARMA1 with, and phosphorylation by, PKCbeta. Furthermore, PKCbeta interacted with the...

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Source

Identifiers

PMID: 16356855
DOI: 10.1016/j.immuni.2005.09.014

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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