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Article

Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation.

Immunity - 1 Dec 2005

Matsumoto Reiko, Wang Donghai, Blonska Marzenna, Li Hongxiu, Kobayashi Masayuki, Pappu Bhanu, Chen Yuhong, Wang Demin, Lin Xin

Abstract excerpt

CARMA1 mediates T cell receptor (TCR)-induced NF-kappaB activation. However, how TCR links to CARMA1 in the signaling pathway is not clear. Here, we show that CARMA1 is inducibly phosphorylated after TCR-CD28 costimulation. This phosphorylation is likely induced by PKCtheta, since PKCtheta induces phosphorylation of CARMA1 in vitro and in vivo. Our results indicate that the PKCtheta-induced phosphorylation of...

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Identifiers

PMID: 16356856
DOI: 10.1016/j.immuni.2005.10.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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