Article
Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.
Proceedings of the National Academy of Sciences of the United States of America - 25 Aug 2009
Brenner Dirk, Brechmann Markus, Röhling Simone, Tapernoux Myriam, Mock Thomas, Winter Dominic, Lehmann Wolf D, Kiefer Friedemann, Thome Margot, Krammer Peter H, Arnold Rüdiger
Abstract excerpt
Activation of the NF-kappaB pathway in T cells is required for induction of an adaptive immune response. Hematopoietic progenitor kinase (HPK1) is an important proximal mediator of T-cell receptor (TCR)-induced NF-kappaB activation. Knock-down of HPK1 abrogates TCR-induced IKKbeta and NF-kappaB activation, whereas active HPK1 leads to increased IKKbeta activity in T cells. Yet, the precise molecular mechanism of...
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