Article
Genetic and epigenetic classifications define clinical phenotypes and determine patient outcomes in colorectal cancer.
The British journal of surgery - 1 Oct 2009
Sanchez J A, Krumroy L, Plummer S, Aung P, Merkulova A, Skacel M, DeJulius K L, Manilich E, Church J M, Casey G, Kalady M F
Abstract excerpt
BACKGROUND: A molecular classification of colorectal cancer has been proposed based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP), and mutations in the KRAS and BRAF oncogenes. This study examined the prevalence of these molecular classes, and differences in clinical presentation and outcome. METHODS: Demographics, tumour characteristics and survival were recorded for 391 subjects...
Topics
- Aged
- Aged, 80 and over
- Colorectal Neoplasms
- CpG Islands
- DNA Methylation
- Epigenesis, Genetic
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Microsatellite Instability