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Article

Distinct genetic profiles in colorectal tumors with or without the CpG island methylator phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2000

Toyota M, Ohe-Toyota M, Ahuja N, Issa J P

Abstract excerpt

Colorectal cancers (CRCs) are characterized by multiple genetic (mutations) and epigenetic (CpG island methylation) alterations, but it is not known whether these evolve independently through stochastic processes. We have recently described a novel pathway termed CpG island methylator phenotype (CIMP) in CRC, which is characterized by the simultaneous methylation of multiple CpG islands, including several known...

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PMID: 10639144
DOI: 10.1073/pnas.97.2.710
PMCID: PMC15395

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THBS1

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