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Article

Unique DNA methylome profiles in CpG island methylator phenotype colon cancers.

Genome research - 1 Feb 2012

Xu Yaomin, Hu Bo, Choi Ae-Jin, Gopalan Banu, Lee Byron H, Kalady Matthew F, Church James M, Ting Angela H

Abstract excerpt

A subset of colorectal cancers was postulated to have the CpG island methylator phenotype (CIMP), a higher propensity for CpG island DNA methylation. The validity of CIMP, its molecular basis, and its prognostic value remain highly controversial. Using MBD-isolated genome sequencing, we mapped and compared genome-wide DNA methylation profiles of normal, non-CIMP, and CIMP colon specimens. Multidimensional scaling...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21990380
DOI: 10.1101/gr.122788.111
PMCID: PMC3266035

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Source receipt: pubmed, retrieved 7 Sept 2026.

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