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Article

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.

Nature genetics - 1 Feb 2015

Takeda Haruna, Wei Zhubo, Koso Hideto, Rust Alistair G, Yew Christopher Chin Kuan, Mann Michael B, Ward Jerrold M, Adams David J, Copeland Neal G, Jenkins Nancy A

Abstract excerpt

To provide a more comprehensive understanding of the genes and evolutionary forces driving colorectal cancer (CRC) progression, we performed Sleeping Beauty (SB) transposon mutagenesis screens in mice carrying sensitizing mutations in genes that act at different stages of tumor progression. This approach allowed us to identify a set of genes that appear to be highly relevant for CRC and to provide a better...

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Identifiers

PMID: 25559195
DOI: 10.1038/ng.3175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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