Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogene

11 Oct 2018

Abstract excerpt

New therapeutic targets for advanced colorectal cancer (CRC) are critically needed. Our laboratory recently performed an insertional mutagenesis screen in mice to identify novel CRC driver genes and, thus, potential drug targets. Here, we define Transmembrane 9 Superfamily 2 (TM9SF2) as a novel CRC oncogene. TM9SF2 is an understudied protein, belonging to a well conserved protein family characterized by their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Ferroptosis and cancer prognosis
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30333512
DOI: 10.1038/s41598-018-33527-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogenePMID 30333512Read ↗

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.Semantic proximity Read ↗

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.Semantic proximity Read ↗

Mouse models for the discovery of colorectal cancer driver genes.Semantic proximity Read ↗

Identification and Comprehensive Analysis of FREM2 Mutation as a Potential Prognostic Biomarker in Colorectal CancerSemantic proximity Read ↗

CRISPR-Cas9–mediated gene knockout in intestinal tumor organoids provides functional validation for colorectal cancer driver genesSemantic proximity Read ↗

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53Semantic proximity Read ↗

MED12 is recurrently mutated in Middle Eastern colorectal cancer.Semantic proximity Read ↗

G9a Is SETting the Stage for Colorectal Oncogenesis.Semantic proximity Read ↗

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.Semantic proximity Read ↗

A Clinically Applicable Gene-Expression Classifier Reveals Intrinsic and Extrinsic Contributions to Consensus Molecular Subtypes in Primary and Metastatic Colon CancerSemantic proximity Read ↗

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter systemSemantic proximity Read ↗

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.