Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.

Biology open - 15 Sept 2025

Risner Alyssa, Nair-Menon Joyce, Cheedipudi Abhinav, Delaney Joe R, Gangaraju Vamsi, Kourtidis Antonis

Abstract excerpt

Reactivation of transposable elements (TEs) in somatic tissues, particularly of LINE-1, is associated with disease by causing gene mutations and DNA damage. Previous work has shown that the PIWI pathway is crucial for TE suppression in the germline. However, the status and function of this pathway is not well characterized in differentiated somatic cells and there is a lack of consensus on the role of the pathway...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Argonaute Proteins
Share to Carcinogenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Computational Biology

Share to DNA Damage

Share to DNA Transposable Elements

Share to Down-Regulation

Share to Long Interspersed Nucleotide Elements

Source

Open in PubMed Open full text

Identifiers

PMID: 40789164
DOI: 10.1242/bio.061942
PMCID: PMC12444863

Genes

PIWIL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes.PMID 40789164Read ↗

PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypesSemantic proximity Read ↗

Transposon mutagenesis identifies genes and evolutionary forces driving gastrointestinal tract tumor progression.Semantic proximity Read ↗

A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.Semantic proximity Read ↗

Integrated Genetic, Epigenetic, and Transcriptional Profiling Identifies Molecular Pathways in the Development of Laterally Spreading Tumors.Semantic proximity Read ↗

Contribution of allelic imbalance to colorectal cancer.Semantic proximity Read ↗

Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancerSemantic proximity Read ↗

PIWIL1 Promotes Gastric Cancer via a piRNA-Independent MechanismSemantic proximity Read ↗

Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancerSemantic proximity Read ↗

Aging restricts colorectal tumor growth by epigenetically silencing developmental gene programsSemantic proximity Read ↗

PIWI Expression and Function in CancerSemantic proximity Read ↗

Transposable elements mediate genetic effects altering the expression of nearby genes in colorectal cancerSemantic proximity Read ↗

Transposon mutagenesis screen in mice identifies TM9SF2 as a novel colorectal cancer oncogeneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.