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Article

Mouse models for the discovery of colorectal cancer driver genes.

World journal of gastroenterology - 14 Jan 2016

Clark Christopher R, Starr Timothy K

Abstract excerpt

Colorectal cancer (CRC) constitutes a major public health problem as the third most commonly diagnosed and third most lethal malignancy worldwide. The prevalence and the physical accessibility to colorectal tumors have made CRC an ideal model for the study of tumor genetics. Early research efforts using patient derived CRC samples led to the discovery of several highly penetrant mutations (e.g., APC, KRAS, MMR...

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Share to Adenomatous Polyposis Coli
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Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 26811627
DOI: 10.3748/wjg.v22.i2.815
PMCID: PMC4716079

Genes

APC
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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