Article
Genomic variants in mouse model induced by azoxymethane and dextran sodium sulfate improperly mimic human colorectal cancer.
Scientific reports - 1 Dec 2017
Pan Qingfei, Lou Xiaomin, Zhang Ju, Zhu Yinghui, Li Fuqiang, Shan Qiang, Chen Xianwei, Xie Yingying, Su Siyuan, Wei Hanfu, Lin Liang, Wu Lin, Liu Siqi
Abstract excerpt
Mouse model induced by azoxymethane (AOM) and dextran sodium sulfate (DSS) is generally accepted as an ideal object to study on the carcinogenesis mechanisms of human colorectal cancer (CRC). The genomic responses to the AOM/DSS treatment in mouse that possibly lead to elucidation of CRC pathological mechanism are still poorly understood. For the first time, we investigated the cancer genome landscape of AOM/DSS...
Topics
- Aberrant Crypt Foci
- Animals
- Azoxymethane
- Colorectal Neoplasms
- Dextran Sulfate
- Genetic Variation
- Humans
- Male
- Mice, Inbred C57BL
- Mutation
- Neoplasms, Experimental
- Exome Sequencing