Article
A Sleeping Beauty transposon-mediated screen identifies murine susceptibility genes for adenomatous polyposis coli (Apc)-dependent intestinal tumorigenesis.
Proceedings of the National Academy of Sciences of the United States of America - 5 Apr 2011
Starr Timothy K, Scott Patricia M, Marsh Benjamin M, Zhao Lei, Than Bich L N, O'Sullivan M Gerard, Sarver Aaron L, Dupuy Adam J, Largaespada David A, Cormier Robert T
Abstract excerpt
It is proposed that a progressive series of mutations and epigenetic events leads to human colorectal cancer (CRC) and metastasis. Furthermore, data from resequencing of the coding regions of human CRC suggests that a relatively large number of mutations occur in individual human CRC, most at low frequency. The functional role of these low-frequency mutations in CRC, and specifically how they may cooperate with...
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