Article
PIWIL2 downregulation in colon cancer promotes transposon activity and pro-tumorigenic phenotypes
2025-05-24
Abstract excerpt
<h4>ABSTRACT</h4> Reactivation of transposable elements (TEs) in somatic tissues, particularly of LINE-1, is associated with disease by causing gene mutations and DNA damage. Previous work has shown that the PIWI pathway is crucial for TE suppression in the germline. However, the status and function of this pathway is not well characterized in differentiated somatic cells and there is lack of consensus on the rol...
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Identifiers and source
- Literature Corpus work
- 231b0c6c-a7a4-50b4-b4c1-854adb2fbaef
- DOI
- 10.1101/2025.05.20.655197