Article
Advances in functional genetic screening with transposons and CRISPR/Cas9 to illuminate cancer biology.
Current opinion in genetics & development - 1 Apr 2018
O'Donnell Kathryn A
Abstract excerpt
Large-scale genome sequencing studies have identified a wealth of mutations in human tumors and have dramatically advanced the field of cancer genetics. However, the functional consequences of an altered gene in tumor progression cannot always be inferred from mutation status alone. This underscores the critical need for complementary methods to assign functional significance to mutated genes in cancer....
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