Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancer.

doi:10.1080/19490976.2024.2341647

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Article

Genetic and microbial determinants of azoxymethane-induced colorectal tumor susceptibility in Collaborative Cross mice and their implication in human cancer.

Gut microbes - 1 Jan 2000

Li Dan, Zhong Chenhan, Yang Mengyuan, He Li, Chang Hang, Zhu Ning, Celniker Susan E, Threadgill David W, Snijders Antoine M, Mao Jian-Hua, Yuan Ying

Abstract excerpt

The insights into interactions between host genetics and gut microbiome (GM) in colorectal tumor susceptibility (CTS) remains lacking. We used Collaborative Cross mouse population model to identify genetic and microbial determinants of Azoxymethane-induced CTS. We identified 4417 CTS-associated single nucleotide polymorphisms (SNPs) containing 334 genes that were transcriptionally altered in human colorectal...

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PMID: 38659246
DOI: 10.1080/19490976.2024.2341647
PMCID: PMC11057575

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