Article
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer.
Science (New York, N.Y.) - 27 Mar 2009
Starr Timothy K, Allaei Raha, Silverstein Kevin A T, Staggs Rodney A, Sarver Aaron L, Bergemann Tracy L, Gupta Mihir, O'Sullivan M Gerard, Matise Ilze, Dupuy Adam J, Collier Lara S, Powers Scott, Oberg Ann L, Asmann Yan W, Thibodeau Stephen N, Tessarollo Lino, Copeland Neal G, Jenkins Nancy A, Cormier Robert T, Largaespada David A
Abstract excerpt
Human colorectal cancers (CRCs) display a large number of genetic and epigenetic alterations, some of which are causally involved in tumorigenesis (drivers) and others that have little functional impact (passengers). To help distinguish between these two classes of alterations, we used a transpos...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.