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Article

Sleeping Beauty Transposon Mutagenesis Identifies Genes Driving the Initiation and Metastasis of Uterine Leiomyosarcoma.

Cancer research - 1 Nov 2021

Kodama Michiko, Shimura Hiroko, Tien Jean C, Newberg Justin Y, Kodama Takahiro, Wei Zhubo, Rangel Roberto, Yoshihara Kosuke, Kuruma Airi, Nakae Aya, Hashimoto Kae, Sawada Kenjiro, Kimura Tadashi, Jenkins Nancy A, Copeland Neal G

Abstract excerpt

Uterine leiomyosarcoma (ULMS) is a malignancy, which arises from the uterine smooth muscle. Because of its rarity, aggressive nature, and extremely poor prognosis, the molecular mechanisms driving ULMS remain elusive. To identify candidate cancer genes (CCG) driving ULMS, we conducted an in vivo Sleeping Beauty (SB) transposon mutagenesis screen in uterine myometrium-specific, PTEN knockout, KRAS mutant (PTEN...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34475109
DOI: 10.1158/0008-5472.CAN-21-0356

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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