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Article

Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene modulates age effects on working memory.

Journal of psychiatric research - 1 Feb 2015

Grimm Simone, Gärtner Matti, Fuge Philipp, Fan Yan, Weigand Anne, Feeser Melanie, Aust Sabine, Heekeren Hauke R, Jacobs Arthur, Heuser Isabella, Bajbouj Malek

Abstract excerpt

Decline in working memory (WM) functions during aging has been associated with hippocampal dysfunction mediated by age-related changes to the corticotropin-releasing hormone (CRH) system. Recent reports suggest that GG-homozygous individuals of single nucleotide polymorphisms (rs110402 and rs242924) in the CRH receptor 1 (CRHR1) gene show increased stress vulnerability and decreased BOLD responses in WM relevant...

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Source

Identifiers

PMID: 25541005
DOI: 10.1016/j.jpsychires.2014.12.001

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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