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Article

Stress and Depression: a Crucial Role of the Mineralocorticoid Receptor.

Journal of neuroendocrinology - 1 Aug 2016

de Kloet E R, Otte C, Kumsta R, Kok L, Hillegers M H J, Hasselmann H, Kliegel D, Joëls M

Abstract excerpt

Cortisol and corticosterone act on the appraisal process, which comprises the selection of an appropriate coping style and the encoding of the experience for storage in the memory. This action exerted by the stress hormones is mediated by mineralocorticoid receptors (MRs), which are expressed abundantly in the limbic circuitry, particularly in the hippocampus. Limbic MR is down-regulated by chronic stress and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26970338
DOI: 10.1111/jne.12379

Genes

CORT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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