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Article

Interaction of early life stress and corticotropin-releasing hormone receptor gene: effects on working memory.

Biological psychiatry - 1 Dec 2014

Fuge Philipp, Aust Sabine, Fan Yan, Weigand Anne, Gärtner Matti, Feeser Melanie, Bajbouj Malek, Grimm Simone

Abstract excerpt

BACKGROUND: Early life stress (ELS) experience is associated with persisting working memory (WM) deficits; changes to the corticotropin-releasing hormone (CRH) system; and structural, functional, and epigenetic changes in the hippocampus. Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS experience to predict depression as well as neuroendocrine and neuronal reactivity. Although...

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Source

Identifiers

PMID: 24931706
DOI: 10.1016/j.biopsych.2014.04.016

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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