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Article

A polymorphism in the Crhr1 gene determines stress vulnerability in male mice.

Endocrinology - 1 Jul 2014

Labermaier Christiana, Kohl Christine, Hartmann Jakob, Devigny Christian, Altmann Andre, Weber Peter, Arloth Janine, Quast Carina, Wagner Klaus V, Scharf Sebastian H, Czibere Ludwig, Widner-Andrä Regina, Brenndörfer Julia, Landgraf Rainer, Hausch Felix, Jones Ken A, Müller Marianne B, Uhr Manfred, Holsboer Florian, Binder Elisabeth B, Schmidt Mathias V

Abstract excerpt

Chronic stress is a risk factor for psychiatric disorders but does not necessarily lead to uniform long-term effects on mental health, suggesting modulating factors such as genetic predispositions. Here we address the question whether natural genetic variations in the mouse CRH receptor 1 (Crhr1) locus modulate the effects of adolescent chronic social stress (ACSS) on long-term stress hormone dysregulation in...

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Source

Identifiers

PMID: 24773341
DOI: 10.1210/en.2013-1986

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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