Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.

doi:10.1016/j.physbeh.2022.113884

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Article

Relations among CRFR1 and FKBP5 genotype, cortisol, and cognitive function in aging humans: A Project FRONTIER study.

Physiology & behavior - 1 Oct 2022

Harris Breanna N, Cooke Jeffrey T, Littlefield Andrew K, Tucker Cody A, Campbell Callie M, King Kaleb S

Abstract excerpt

Here we use the glucocorticoid cascade hypothesis framework to address the role of baseline cortisol on changes in cognitive function over a 3-year span in non-demented rural Americans. We also determine if genotype at 4 different single nucleotide polymorphisms (SNPs) relates to change in cognitive function. We predicted 1) over time, increases in baseline cortisol will be associated with decline in cognitive...

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Share to CRF Receptor, Type 1
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Receptors, Corticotropin-Releasing Hormone

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PMID: 35718217
DOI: 10.1016/j.physbeh.2022.113884

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