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Article

The interaction of corticotropin-releasing hormone receptor gene and early life stress on emotional empathy.

Behavioural brain research - 30 Jun 2017

Grimm Simone, Wirth Katharina, Fan Yan, Weigand Anne, Gärtner Matti, Feeser Melanie, Dziobek Isabel, Bajbouj Malek, Aust Sabine

Abstract excerpt

Early life stress (ELS) is associated with increased vulnerability for depression, changes to the corticotropin-releasing hormone (CRH) system and structural and functional changes in hippocampus. Single nucleotide polymorphisms in the CRH receptor 1 (CRHR1) gene interact with ELS to predict depression, cognitive functions and hippocampal activity. Social cognition has been related to hippocampal function and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28461011
DOI: 10.1016/j.bbr.2017.04.047

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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