Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing.

doi:10.1523/JNEUROSCI.5533-11.2012

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Article

Variation in the corticotropin-releasing hormone receptor 1 (CRHR1) gene influences fMRI signal responses during emotional stimulus processing.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 29 Feb 2012

Hsu David T, Mickey Brian J, Langenecker Scott A, Heitzeg Mary M, Love Tiffany M, Wang Heng, Kennedy Susan E, Peciña Marta, Shafir Tal, Hodgkinson Colin A, Enoch Mary-Anne, Goldman David, Zubieta Jon-Kar

Abstract excerpt

The corticotropin-releasing hormone (CRH) system coordinates neuroendocrine and behavioral responses to stress and has been implicated in the development of major depressive disorder (MDD). Recent reports suggest that GG-homozygous individuals of a single nucleotide polymorphism (rs110402) in the CRH receptor 1 (CRHR1) gene show behavioral and neuroendocrine evidence of stress vulnerability. The present study...

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Identifiers

PMID: 22378896
DOI: 10.1523/JNEUROSCI.5533-11.2012
PMCID: PMC3297975

Genes

CRHR1
CRH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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