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Article

Association of gene variants of the renin-angiotensin system with accelerated hippocampal volume loss and cognitive decline in old age.

The American journal of psychiatry - 1 Nov 2014

Zannas Anthony S, McQuoid Douglas R, Payne Martha E, MacFall James R, Ashley-Koch Allison, Steffens David C, Potter Guy G, Taylor Warren D

Abstract excerpt

OBJECTIVE: Genetic factors confer risk for neuropsychiatric phenotypes, but the polygenic etiology of these phenotypes makes identification of genetic culprits challenging. An approach to this challenge is to examine the effects of genetic variation on relevant endophenotypes, such as hippocampal volume loss. A smaller hippocampus is associated with gene variants of the renin-angiotensin system (RAS), a system...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25124854
DOI: 10.1176/appi.ajp.2014.13111543
PMCID: PMC4329281

Genes

AGTR1
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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