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Mental performance in old age dependent on cortisol and genetic variance in the mineralocorticoid and glucocorticoid receptors.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jun 2007

Kuningas Maris, de Rijk Roel H, Westendorp Rudi G J, Jolles Jelle, Slagboom P Eline, van Heemst Diana

Abstract excerpt

Depression and cognitive decline have been associated with changes in circulating cortisol concentrations. Cortisol exerts its functions through mineralocorticoid (MR) and glucocorticoid (GR) receptors. However, data on the influence of variations in the MR and GR genes on depressive symptoms and...

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PMID: 17133261
DOI: 10.1038/sj.npp.1301260

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17133261-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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