DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

doi:10.1016/j.celrep.2014.11.004

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Article

DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia.

Cell reports - 11 Dec 2014

Rampal Raajit, Alkalin Altuna, Madzo Jozef, Vasanthakumar Aparna, Pronier Elodie, Patel Jay, Li Yushan, Ahn Jihae, Abdel-Wahab Omar, Shih Alan, Lu Chao, Ward Patrick S, Tsai Jennifer J, Hricik Todd, Tosello Valeria, Tallman Jacob E, Zhao Xinyang, Daniels Danette, Dai Qing, Ciminio Luisa, Aifantis Iannis, He Chuan, Fuks Francois, Tallman Martin S, Ferrando Adolfo, Nimer Stephen, Paietta Elisabeth, Thompson Craig B, Licht Jonathan D, Mason Christopher E, Godley Lucy A, Melnick Ari, Figueroa Maria E, Levine Ross L

Abstract excerpt

Somatic mutations in IDH1/IDH2 and TET2 result in impaired TET2-mediated conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). The observation that WT1 inactivating mutations anticorrelate with TET2/IDH1/IDH2 mutations in acute myeloid leukemia (AML) led us to hypothesize that WT1 mutations may impact TET2 function. WT1 mutant AML patients have reduced 5hmC levels similar to TET2/IDH1/IDH2...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25482556
DOI: 10.1016/j.celrep.2014.11.004
PMCID: PMC4267494

Genes

TET2
IDH1
IDH2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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