Article
WT1 recruits TET2 to regulate its target gene expression and suppress leukemia cell proliferation.
Molecular cell - 19 Feb 2015
Wang Yiping, Xiao Mengtao, Chen Xiufei, Chen Leilei, Xu Yanping, Lv Lei, Wang Pu, Yang Hui, Ma Shenghong, Lin Huaipeng, Jiao Bo, Ren Ruibao, Ye Dan, Guan Kun-Liang, Xiong Yue
Abstract excerpt
The TET2 DNA dioxygenase regulates cell identity and suppresses tumorigenesis by modulating DNA methylation and expression of a large number of genes. How TET2, like most other chromatin-modifying enzymes, is recruited to specific genomic sites is unknown. Here we report that WT1, a sequence-specific transcription factor, is mutated in a mutually exclusive manner with TET2, IDH1, and IDH2 in acute myeloid...
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