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Article

TET proteins and 5-methylcytosine oxidation in hematological cancers.

Immunological reviews - 1 Jan 2015

Ko Myunggon, An Jungeun, Pastor William A, Koralov Sergei B, Rajewsky Klaus, Rao Anjana

Abstract excerpt

DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon silencing, genomic imprinting, and X-chromosome inactivation. Cancer cells display highly dysregulated DNA methylation profiles characterized by global hypomethylation in conjunction with hypermethylation of promoter CpG islands that presumably lead to genome instability and aberrant expression of tumor suppressor genes or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25510268
DOI: 10.1111/imr.12239
PMCID: PMC4617313

Genes

TET2
TET3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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