Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

doi:10.1038/nature09586

Article

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Nature - 9 Dec 2010

Ko Myunggon, Huang Yun, Jankowska Anna M, Pape Utz J, Tahiliani Mamta, Bandukwala Hozefa S, An Jungeun, Lamperti Edward D, Koh Kian Peng, Ganetzky Rebecca, Liu X Shirley, Aravind L, Agarwal Suneet, Maciejewski Jaroslaw P, Rao Anjana

Abstract excerpt

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative...

Topics

5-Methylcytosine
Animals
Biocatalysis
Cell Differentiation
Cell Line
CpG Islands
DNA Methylation
DNA, Neoplasm
DNA-Binding Proteins
Dioxygenases

Humans

Hydroxylation

Leukemia, Myeloid, Acute

Mice

Mice, Inbred C57BL

Mutant Proteins

Mutation

Myelodysplastic Syndromes

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