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Article

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2.

Nature - 9 Dec 2010

Ko Myunggon, Huang Yun, Jankowska Anna M, Pape Utz J, Tahiliani Mamta, Bandukwala Hozefa S, An Jungeun, Lamperti Edward D, Koh Kian Peng, Ganetzky Rebecca, Liu X Shirley, Aravind L, Agarwal Suneet, Maciejewski Jaroslaw P, Rao Anjana

Abstract excerpt

TET2 is a close relative of TET1, an enzyme that converts 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) in DNA. The gene encoding TET2 resides at chromosome 4q24, in a region showing recurrent microdeletions and copy-neutral loss of heterozygosity (CN-LOH) in patients with diverse myeloid malignancies. Somatic TET2 mutations are frequently observed in myelodysplastic syndromes (MDS), myeloproliferative...

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Source

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Identifiers

PMID: 21057493
DOI: 10.1038/nature09586
PMCID: PMC3003755

Genes

TET2
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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