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Article

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.

Cancer cell - 14 Dec 2010

Figueroa Maria E, Abdel-Wahab Omar, Lu Chao, Ward Patrick S, Patel Jay, Shih Alan, Li Yushan, Bhagwat Neha, Vasanthakumar Aparna, Fernandez Hugo F, Tallman Martin S, Sun Zhuoxin, Wolniak Kristy, Peeters Justine K, Liu Wei, Choe Sung E, Fantin Valeria R, Paietta Elisabeth, Löwenberg Bob, Licht Jonathan D, Godley Lucy A, Delwel Ruud, Valk Peter J M, Thompson Craig B, Levine Ross L, Melnick Ari

Abstract excerpt

Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production. Mutational and epigenetic profiling of a large acute myeloid leukemia (AML) patient cohort revealed that IDH1/2-mutant AMLs display global DNA hypermethylation and a...

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Source

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Identifiers

PMID: 21130701
DOI: 10.1016/j.ccr.2010.11.015
PMCID: PMC4105845

Genes

IDH1
TET2
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21130701-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation.PMID 21130701Read ↗

Distinct and opposite effects of leukemogenic Idh and Tet2 mutations in hematopoietic stem and progenitor cells.Semantic proximity Read ↗

The role of mutant IDH1 and IDH2 inhibitors in the treatment of acute myeloid leukemia.Semantic proximity Read ↗

IDH2 mutation-induced histone and DNA hypermethylation is progressively reversed by small-molecule inhibition.Semantic proximity Read ↗

Roles of IDH1/2 and TET2 mutations in myeloid disorders.Semantic proximity Read ↗

AG-221, a Small Molecule Mutant IDH2 Inhibitor, Remodels the Epigenetic State of IDH2-Mutant Cells and Induces Alterations in Self-Renewal/Differentiation in IDH2-Mutant AML Model in VivoSemantic proximity Read ↗

IDH2 mutations in acute myeloid leukemia.Semantic proximity Read ↗

Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.Semantic proximity Read ↗

The role of IDH mutations in acute myeloid leukemia.Semantic proximity Read ↗

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical PerspectivesSemantic proximity Read ↗

(R)-2-Hydroxyglutarate Inhibits KDM5 Histone Lysine Demethylases to Drive Transformation in IDH-Mutant Cancers.Semantic proximity Read ↗

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation.Semantic proximity Read ↗

Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL.Semantic proximity Read ↗

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