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Article

Characterization of acute myeloid leukemia based on levels of global hydroxymethylation.

Blood - 14 Aug 2014

Kroeze Leonie I, Aslanyan Mariam G, van Rooij Arno, Koorenhof-Scheele Theresia N, Massop Marion, Carell Thomas, Boezeman Jan B, Marie Jean-Pierre, Halkes Constantijn J M, de Witte Theo, Huls Gerwin, Suciu Stefan, Wevers Ron A, van der Reijden Bert A, Jansen Joop H

Abstract excerpt

Patients with acute myeloid leukemia (AML) frequently harbor mutations in genes involved in the DNA (hydroxy)methylation pathway (DNMT3A, TET2, IDH1, and IDH2). In this study, we measured 5-hydroxymethylcytosine (5hmC) levels in 206 clinically and molecularly well-characterized younger adult AML patients (≤60 years) included in the European Organization for Research and Treatment of Cancer/Gruppo Italiano...

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Source

Identifiers

PMID: 24986689
DOI: 10.1182/blood-2013-08-518514

Genes

TET2
IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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