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Article

Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.

Blood - 8 Jan 2015

Sinha Subarna, Thomas Daniel, Yu Linda, Gentles Andrew J, Jung Namyoung, Corces-Zimmerman M Ryan, Chan Steven M, Reinisch Andreas, Feinberg Andrew P, Dill David L, Majeti Ravindra

Abstract excerpt

Acute myeloid leukemia (AML) is associated with deregulation of DNA methylation; however, many cases do not bear mutations in known regulators of cytosine guanine dinucleotide (CpG) methylation. We found that mutations in WT1, IDH2, and CEBPA were strongly linked to DNA hypermethylation in AML using a novel integrative analysis of The Cancer Genome Atlas data based on Boolean implications, if-then rules that...

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Share to DNA Methylation
Share to Enhancer of Zeste Homolog 2 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Expression Regulation, Leukemic

Share to Genes, Wilms Tumor

Share to Leukemia, Myeloid, Acute

Share to Oligonucleotide Array Sequence Analysis

Share to Polycomb Repressive Complex 2

Source

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Identifiers

PMID: 25398938
DOI: 10.1182/blood-2014-03-566018
PMCID: PMC4287638

Genes

IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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