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Article

Perturbations of 5-hydroxymethylcytosine patterning in hematologic malignancies.

Seminars in hematology - 1 Jan 2013

Madzo Jozef, Vasanthakumar Aparna, Godley Lucy A

Abstract excerpt

The recent identification of covalent cytosine modifications derived from the metabolism of 5-methylcytosine (5-mC) and catalyzed by the TET proteins has facilitated molecular insight into a new subclass of acute myeloid leukemias (AMLs). TET2-mutant AMLs have the predicted hypermethylation phenotype expected given the inability of the mutant TET2 protein to convert 5-mC to 5-hydroxymethylcytosine (5-hmC). In...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23507484
DOI: 10.1053/j.seminhematol.2013.01.004

Genes

TET2
IDH1

Provenance

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