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Article

Immunohistochemical loss of 5-hydroxymethylcytosine expression in acute myeloid leukaemia: relationship to somatic gene mutations affecting epigenetic pathways.

Histopathology - 1 Dec 2016

Magotra Minoti, Sakhdari Ali, Lee Paul J, Tomaszewicz Keith, Dresser Karen, Hutchinson Lloyd M, Woda Bruce A, Chen Benjamin J

Abstract excerpt

AIMS: Genes affecting epigenetic pathways are frequently mutated in myeloid malignancies, including acute myeloid leukaemia (AML). The genes encoding TET2, IDH1 and IDH2 are among the most commonly mutated genes, and cause defective conversion of 5-methylcytosine into 5-hydroxymethylcytosine (5hmC), impairing demethylation of DNA, and presumably serving as driver mutations in leukaemogenesis. The aim of this...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

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Share to History, 17th Century

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Share to Leukemia, Myeloid, Acute

Source

Identifiers

PMID: 27458708
DOI: 10.1111/his.13046

Genes

TET2
IDH1
IDH2

Provenance

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