Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.

doi:10.1016/j.neuron.2014.10.032

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Article

Conserved higher-order chromatin regulates NMDA receptor gene expression and cognition.

Neuron - 3 Dec 2014

Bharadwaj Rahul, Peter Cyril J, Jiang Yan, Roussos Panos, Vogel-Ciernia Annie, Shen Erica Y, Mitchell Amanda C, Mao Wenjie, Whittle Catheryne, Dincer Aslihan, Jakovcevski Mira, Pothula Venu, Rasmussen Theodore P, Giakoumaki Stella G, Bitsios Panos, Sherif Ajfar, Gardner Paul D, Ernst Patricia, Ghose Subroto, Sklar Pamela, Haroutunian Vahram, Tamminga Carol, Myers Richard H, Futai Kensuke, Wood Marcelo A, Akbarian Schahram

Abstract excerpt

Three-dimensional chromosomal conformations regulate transcription by moving enhancers and regulatory elements into spatial proximity with target genes. Here we describe activity-regulated long-range loopings bypassing up to 0.5 Mb of linear genome to modulate NMDA glutamate receptor GRIN2B expression in human and mouse prefrontal cortex. Distal intronic and 3' intergenic loop formations competed with repressor...

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Identifiers

PMID: 25467983
DOI: 10.1016/j.neuron.2014.10.032
PMCID: PMC4258154

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