Article

High-resolution genome topology of human retina uncovers super enhancer-promoter interactions at tissue-specific and multifactorial disease loci

2022-06-17

Abstract excerpt

<title>Abstract</title> Chromatin organization and enhancer-promoter contacts establish unique spatiotemporal gene expression patterns in distinct cell types. Non-coding genetic variants can influence cellular phenotypes by modifying higher-order transcriptional hubs and consequently gene expression. To elucidate genomic regulation in human retina, we mapped chromatin contacts at high resolution and integrated...

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Literature Corpus work: 69b960b5-971b-57a6-b5e9-27031283050c
DOI: 10.21203/rs.3.rs-1650982/v1

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