Whole genome functional characterization of RE1 silencers using a modified massively parallel reporter assay

Abstract excerpt

Both upregulation and downregulation by cis -regulatory elements help establish precise gene expression. Our understanding of how elements repress transcriptional activity is far more limited than activating elements. To address this gap, we characterized RE1, a group of transcriptional silencers bound by REST, on a genome-wide scale using an modified massively parallel reporter assay (MPRAduo). MPRAduo empirical...

Topics

Open a Topic to create a Post that cites this publication.

• Binding Sites
• Disease
• Gene Regulatory Networks
• Genome, Human
• Nucleotide Motifs
• Oligonucleotide Array Sequence Analysis
• Regulatory Sequences, Nucleic Acid
• Repressor Proteins

Identifiers and source

Literature Corpus work

45ed4e8c-50cf-5a0d-9756-5ec6c57609cc

DOI

10.1101/2022.02.11.479757