The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

doi:10.1038/ng.3906

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Article

The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.

Nature genetics - 1 Aug 2017

Jiang Yan, Loh Yong-Hwee Eddie, Rajarajan Prashanth, Hirayama Teruyoshi, Liao Will, Kassim Bibi S, Javidfar Behnam, Hartley Brigham J, Kleofas Lisa, Park Royce B, Labonte Benoit, Ho Seok-Man, Chandrasekaran Sandhya, Do Catherine, Ramirez Brianna R, Peter Cyril J, C W Julia T, Safaie Brian M, Morishita Hirofumi, Roussos Panos, Nestler Eric J, Schaefer Anne, Tycko Benjamin, Brennand Kristen J, Yagi Takeshi, Shen Li, Akbarian Schahram

Abstract excerpt

We report locus-specific disintegration of megabase-scale chromosomal conformations in brain after neuronal ablation of Setdb1 (also known as Kmt1e; encodes a histone H3 lysine 9 methyltransferase), including a large topologically associated 1.2-Mb domain conserved in humans and mice that encompasses >70 genes at the clustered protocadherin locus (hereafter referred to as cPcdh). The cPcdh topologically...

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PMID: 28671686
DOI: 10.1038/ng.3906
PMCID: PMC5560095

Genes

SETDB1
CTCF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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