Article

Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neurons

2025-10-01

Abstract excerpt

Persistent molecular correlates of long-term memory storage remain an open question. Here, we stimulate and re-stimulate human neurons and use multi-modal single-nucleus technologies to query DNA methylation, higher-order chromatin folding, and gene expression. We find enduring traces of activity-gained and activity-lost chromatin loops. Genes anchoring persistent activity-gained loops exhibit activity-upregulated...

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Literature Corpus work: 0ae05ef2-cdf1-5a9d-b70f-e3632ddda6c9
DOI: 10.1101/2025.09.30.679661

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