Article

A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer’s disease mutations

2024-02-27

Abstract excerpt

Mammalian genomes fold into tens of thousands of long-range loops, but their functional role and physiologic relevance remain poorly understood. Here, using human post-mitotic neurons with rare familial Alzheimer’s disease (FAD) mutations, we identify hundreds of reproducibly dysregulated genes and thousands of miswired loops prior to amyloid accumulation and tau phosphorylation. Single loops do not predict expres...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76281fd5-a010-55a4-b036-b32a77d2ade6
DOI: 10.1101/2024.02.27.582395

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A multi-looping chromatin signature predicts dysregulated gene expression in neurons with familial Alzheimer’s disease mutationsDOI 10.1101/2024.02.27.582395Read

Single nucleus multiomics identifies ZEB1 and MAFB as candidate regulators of Alzheimer’s disease-specific cis regulatory elementsSemantic proximity Read

Silencer variants are key drivers of gene up-regulation in Alzheimer's disease.Semantic proximity Read

The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression.Semantic proximity Read

Widespread transposable element dysregulation in human aging brains with Alzheimer's diseaseSemantic proximity Read

Long-Range Enhancer Networks Gradually Emerge as Key Regulators During Human Cortical NeurogenesisSemantic proximity Read

Persistent chromatin loops shape gene expression plasticity upon stimulation and restimulation of human neuronsSemantic proximity Read

A human neuronal model of sporadic Alzheimer’s disease induced by FBXO2 downregulation shows Aβ aggregation, tau hyperphosphorylation and functional network impairmentSemantic proximity Read

Identification of Parkinson’s disease-associated regulatory variants in human dopaminergic neurons reveals modulators of SCARB2 and BAG3 expressionSemantic proximity Read

Identification of enhancer chromatin signatures involved in dopaminergic induction through multi-omics analysisSemantic proximity Read

Context-dependent regulatory variants in Alzheimer’s diseaseSemantic proximity Read

Enhancer variants associated with Alzheimer’s disease affect gene expression via chromatin loopingSemantic proximity Read