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Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression

18 Sept 2023

Abstract excerpt

Paneth cells (PCs), a specialized secretory cell type in the small intestine, are increasingly recognized as having an essential role in host responses to microbiome and environmental stresses. Whether and how commensal and pathogenic microbes modify PC composition to modulate inflammation remain unclear. Using newly developed PC-reporter mice under conventional and gnotobiotic conditions, we determined PC...

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PMID: 37718683
DOI: 10.15252/embj.2023113975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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