Article
Commensal microbes drive intestinal inflammation by IL-17-producing CD4+ T cells through ICOSL and OX40L costimulation in the absence of B7-1 and B7-2.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jul 2014
Xin Lijun, Jiang Tony T, Chaturvedi Vandana, Kinder Jeremy M, Ertelt James M, Rowe Jared H, Steinbrecher Kris A, Way Sing Sing
Abstract excerpt
The costimulatory B7-1 (CD80)/B7-2 (CD86) molecules, along with T-cell receptor stimulation, together facilitate T-cell activation. This explains why in vivo B7 costimulation neutralization efficiently silences a variety of human autoimmune disorders. Paradoxically, however, B7 blockade also potently moderates accumulation of immune-suppressive regulatory T cells (Tregs) essential for protection against...
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