Article

Endothelial c-IAP2 Loss Amplifies P2X7 Receptor-Driven Inflammation and Worsens Infection-Associated Pulmonary Hypertension

2025-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Schistosomiasis-associated Pulmonary Hypertension (Sch-PH) is the most common form of group I PH worldwide. Recently, data revealed that the preclinical animal model of Sch-PH exhibited gut and lung microbiome dysbiosis linked to significant endothelial dysfunction and microvascular apoptosis, but the role of pro/anti-apoptosis sensors, such as the inhibitor of apoptosis protein 2 (c-IAP2) and p...

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Literature Corpus work: 33c2d455-86d7-57c0-9f06-f5c9e7d85e31
DOI: 10.1101/2025.05.22.655387

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