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Article

IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39/ATP axis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2013

Younas Mehwish, Hue Sophie, Lacabaratz Christine, Guguin Aurélie, Wiedemann Aurélie, Surenaud Mathieu, Beq Stéphanie, Croughs Thérèse, Lelièvre Jean-Daniel, Lévy Yves

Abstract excerpt

The heterogeneity of human regulatory T cells (Tregs) may explain the discrepancies between studies on Tregs in physiology and pathology. Contrasting effects of IL-7 on the expansion and survival of human Tregs were reported. Therefore, we investigated the effects of IL-7 on the phenotype and function of well-characterized populations of human Tregs. We show that IL-7 signals via the CD127 receptor on naive,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23966629
DOI: 10.4049/jimmunol.1203547

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