Article

Antigen receptor signaling and cell death resistance controls intestinal humoral response zonation

2023-03-16

Abstract excerpt

Immunoglobulin A (IgA), the main antibody isotype found in the intestine, has evolved to maintain the stability of commensal communities, and prevent dysbiosis. In stark contrast to systemic antibody response against pathogens, the generation of IgA against intestinal resident microbes assures the simultaneous binding to multiple and diverse commensal-derived antigens. However, the exact mechanisms by which B cell...

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Literature Corpus work: 62f112fc-ec2d-57bf-b0f7-017e8a8cfcb2
DOI: 10.1101/2023.03.16.532481

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